Titlebook: Cytokines and Colony Stimulating Factors; Methods and Protocol Dieter K?rholz,Wieland Kiess Book 2003 Humana Press 2003

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Apoptosis Induction by TRAILious cancer cell lines (.-.). However, in contrast to injection of TNF or CD95L, which are both lethal to mice (.), TRAIL exerts potent antitumor activity in vivo without exhibiting systemic toxicity (.-.). Thus, treatment with TRAIL might be a promising therapeutic approach for many solid tumors.

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GUMP

Intracellular Detection of T-Cell Cytokinesther important feature for characterizing cellular function. The development of multicolor cytometers as well as the growing number of fluorochromes and dyes makes it possible to perform more complex analyses.

Addictive

Experimental Strategies for Combined Suicide and Immune Cancer Gene Therapyled bystander effect. The bystander effect (.) describes the phenomenon that in cell culture only a relatively small amount of cells has to be transduced with the suicide gene to gain complete cell killing upon treatment with the corresponding prodrug.

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Book 2003isms as well as aberrant cell clones. The roots of immunologic investigations reach far into the past. In 430 BC, Thucydides reported that survivors of the plague did not present a second time with similar symptoms. The first report of a successful immu- therapy was made by Edward Jenner in 1798 who

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Primary Immunodeficiencies Caused by Defects of Cytokines and Cytokine Receptors phagocytes. Cytokines and their respective receptors are intimately involved in regulating such immune responses. Their pivotal role can be illustrated in animal models for which certain cytokines or their receptors have been deleted.

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Intracellular Detection of T-Cell Cytokines surface marker expression to define certain cellular subsets in basic research as well as in clinical settings, more complex assays have been developed in recent years to analyze, for example, physiological responses, apoptosis, or cell cycling (.-.). The expression of intracellular proteins is ano

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