Titlebook: Cytokeratins in Intracranial and Intraspinal Tissues; Michael Kasper Book 1992 The Editor(s) (if applicable) and The Author(s), under excl

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The Arachnoidea, or the neural crest (Leikola 1976; Bargmann et al. 1982). Both kinds of neurothelial cells, the arachnoidal cells of the CNS as well as the perineurial cells of the peripheral nerves, are characterized by the abundancy of intermediate filaments.

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Cytokeratin in Glial Cells and in Tumors of Glial Origin,. This glial cell type forms desmosomes connected to intermediate filament bundles, as revealed by electron microscopy. Other astrocytes in the same species contain GFAP as the predominant intermediate filament protein. Giordano et al. (1989) have now reported the complete sequence of a glial filame

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Cytokeratins in Nerve Cells,ear (Anniko et al. 1990b) using the antibody RCK106 (see Table 2). Moreover, the authors also found cytokeratin 10/11 reactivity, but could not show any biochemical confirmation of this finding. Additionally, coexpression of vimentin and NFs was noted.

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Neural Crest Derivatives,r review see Achtstaetter et al. 1986). It is still not known whether any other neuronal crest derivative in adult tissues is able to express cytokeratins, excepting the arachnoidal cells and the corneal endothelium (see Chap. 8; Zwaan and Webster 1985; Shamsuddin et al. 1986; Kasper et al. 1992b).

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Cytokeratin Expression in Tumors of Neuroectodermal Origin, oligodendrocytes, and ependymal cells) and the nerve cells. The corresponding tumors are gliomas, medulloblastomas, neuroblastomas, and ganglioneuromas. In this group, the primitive neuroectodermal tumors (PNETs) are regarded as an entity of closely related members sharing highly significant neuroe

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Conclusions,ssical neuroectodermal cells in human and higher vertebrate brain tissue and in many tumors of neuroectodermal origin are stained by corresponding poly- and monoclonal antibodies. The evaluation of this keratin pair offers a tool of choice for the monitoring of differentiation processes in neuroecto

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Summary,their histogenesis, and their malignant transformation. In the case of cytokeratins, the characteristic epithelial intermediate filaments representing a complex group of about 30 polypeptides, extensive attention has been given to their expression in diverse epithelial and epithelioid cells. However

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Neural Crest Derivatives,Furthermore, the Merkel’s cells of the skin express cytokeratins, but there is controversy regarding their neural crest origin (I. Moll et al. 1990). The adrenal medulla lacks cytokeratins (Miettinen et al. 1985b).