Titlebook: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism; Aparajita Dey Book 2013 Springer Science+Business Media Dordrecht 2013 Cytoc

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Cytochrome P450 2E1: Its Clinical Aspects and a Brief Perspective on the Current Research Scenario, modulation of drug efficacy. Studies involving these interesting facets of CYP2E1 have been discussed in the chapter focusing on the recent observations or ongoing studies illustrating the crucial role of CYP2E1 in disease development and drug metabolism.

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The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Rtration of ethanol and drugs. Induction of CYP2E1 leads to prominent epigenetic effects and CYP2E1 polymorphism may be associated with alcoholic liver disease. These are some aspects of CYP2E1, amongst many others which account for its importance in the context of drug metabolism and disease development and have been reviewed in the chapter.

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A. Hall,L. W. Busse,M. Ostermann modulation of drug efficacy. Studies involving these interesting facets of CYP2E1 have been discussed in the chapter focusing on the recent observations or ongoing studies illustrating the crucial role of CYP2E1 in disease development and drug metabolism.

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Book 2013bolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

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S. A. M. Dhaese,V. Stove,J. J. De Waeled could be prevented by antioxidants and potentiated if glutathione (GSH) was removed. The E47 cells had higher GSH levels and a Twofold increase in catalase, cytosolic and microsomal glutathione transferase, and heme oxygenase-1 (HO-1) than control HepG2 cells due to activation of their respective

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B. Hamilton,L. B. Ware,M. A. Matthayin diets and in tobacco smoke to their carcinogenic metabolites. Among these, nitrosamines seem to be the most important carcinogens. CYP2E1 also degrades retinoic acid and retinol to polar metabolites. Metabolism of retinoic acid not only results in the loss of retinoic acid promoting carcinogenesi

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P. Formenti,M. Brioni,D. Chiumelloignificance was not achieved because of small sample sizes. Some more indirect data also suggests a relationship between high CYP2E1 activity and progression to NASH. However, three recent genome-wide association studies on NAFLD have failed to find any evidence that single nucleotide polymorphisms

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Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity,d could be prevented by antioxidants and potentiated if glutathione (GSH) was removed. The E47 cells had higher GSH levels and a Twofold increase in catalase, cytosolic and microsomal glutathione transferase, and heme oxygenase-1 (HO-1) than control HepG2 cells due to activation of their respective