Titlebook: Cystic Fibrosis; Diagnosis and Protoc Margarida D. Amaral,Karl Kunzelmann Book 2011 Springer Science+Business Media, LLC 2011 CF.CFTR expre

把手

Parasitic Protozoa in Macrophages in vitroome correctors appear to function as pharmacological chaperones that specifically bind to the CFTR processing mutants and induce them to complete the folding process. In this chapter, we describe techniques to examine the effects of correctors on folding of CFTR processing mutants.

向下

Da-Zhi Liu,Bradley P. Ander,Frank R. Sharper concentrates on methods for evaluating microRNA regulation of gene expression in the context of airway disease. The final chapter considers methods to evaluate the chromatin structure of the active . locus and to analyse the .-acting regulatory elements that control it

Agility

合乎習(xí)俗

嗎啡

Urveshkumar D. Patel,M. R. Srinivasanres of the CF phenotype. NPD measurement is an important in vivo research and diagnostic tool, and is used to assess the efficacy of new treatments such as gene therapy and ion transport modulators. This chapter will elaborate on the electrophysiological principles behind the test, the equipment required, the methods, and the analysis of the data.

滋養(yǎng)

乞丐

meritorious

High-Throughput Screening of Libraries of Compounds to Identify CFTR Modulatorsthe halide sensitivity of the yellow fluorescent protein (YFP). CFTR activity can be simply assessed by measuring the rate of YFP signal decrease caused by iodide influx. This assay can be automated to test thousands of compounds per day.

斜谷

Repair of CFTR Folding Defects with Correctors that Function as Pharmacological Chaperonesome correctors appear to function as pharmacological chaperones that specifically bind to the CFTR processing mutants and induce them to complete the folding process. In this chapter, we describe techniques to examine the effects of correctors on folding of CFTR processing mutants.

能量守恒