Titlebook: Contemporary Neuroma Management; Kyle R. Eberlin,Ivica Ducic,Gregory A. Dumanian Book 2024 The Editor(s) (if applicable) and The Author(s)

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https://doi.org/10.1007/978-3-319-72935-0esearch investigation. A basic spectrum of antibodies that can be included to identify essential components of nerve include PGP 9.5, neurofilaments, beta-III tubulin, S100β, collagens, and laminin. Additionally, molecular histology can distinguish motor versus sensory axons, as well as differences

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Peripheral Sensitization: Peripheral Mechanisms of Neuroma and Neuropathic Pain axons from the proximal segment of the injured nerve become entangled in scar tissue, forming a neuroma. Nociceptors within the neuroma may become sensitized by prolonged noxious stimulation leading to hyperalgesia and allodynia. This chapter describes the mechanical, biochemical, and electrophysio

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Clinical Diagnosis of Symptomatic Neuromaa or prior surgery. Pain quality consistent with neuroma includes diminished sensation, paresthesias, dysesthesias, and hyperalgesia distal to the site of presumed nerve injury. History should also address duration, frequency, and intensity of symptoms; response to prior treatment attempts; response