Titlebook: Congenital Heart Diseases: The Broken Heart; Clinical Features, H Silke Rickert-Sperling,Robert G. Kelly,Nikolaus Ha Book 2024Latest editio

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Deciphering Congenital Heart Disease Using Human Induced Pluripotent Stem Cellsnt of CHD are complex and remain elusive due to a lack of efficient, reproducible, and translational model systems. Investigations relied on animal models have inherent limitations due to interspecies differences. Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for

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Human Genetics of Congenital Heart Defectst at birth. CHDs include an extensive range of defects that may be minor and require no intervention or may be life-limiting and require complex surgery shortly after birth. This chapter reviews the current knowledge on the genetic causes of CHD.

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Cardiac Development and Animal Models of Congenital Heart DefectsThe major events of cardiac development, including early heart formation, chamber morphogenesis and septation, and conduction system and coronary artery development, are briefly reviewed together with a short introduction to the animal species commonly used to study heart development and model congenital heart defects (CHDs).

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Congenital Heart Diseases: The Broken Heart978-3-031-44087-8Series ISSN 0065-2598 Series E-ISSN 2214-8019