Titlebook: Cyclic Peptide Design; Gilles Goetz Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug design.Small molecul

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Click Chemistry for Cyclic Peptide Drug Design,cyclic peptidomimetic compounds. The usage of “click chemistry” reactions includes various topics: (a) mimicking peptide bonds; (b) synthesis of ordered structures; (c) ligation of peptidomimetic scaffolds; and most importantly in this chapter (d) cyclization of peptidomimetic scaffolds using the triazole ring as constraint of conformation.

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Jinghang Lu,Baoze Wei,Xiaochao Hou,Yao Sunon and macrocyclization in order to limit a peptide’s conformational possibilities, to increase its chemical and enzymatic stability, to prolong the time of action, and to increase activity and selectivity toward the receptor.