Titlebook: Cyclic Nucleotides; Part II: Physiology John W. Kebabian,James A. Nathanson Book 1982 Springer-Verlag Berlin Heidelberg 1982 biochemistry.

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Regulation of Water and Electrolyte Movement by Vasopressin and Cyclic Nucleotides in Kidneynylyl cyclase. The change in receptor affinity is prevented by hypertonic NaCl. It is conceivable that the degree of hypertonicity of the renal medulla in vivo may regulate ADH binding..Prostaglandins inhibit ADH-stimulation of water flow in toad bladder and renal collecting duct, presumably by inhi

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Regulation of Cellular Excitability by Cyclic Nucleotidest (usually Ca.) conductances generally associated with generation or prolongation of action potentials. Responses to cyclic GMP remain more covert, although in many cell types depolarization is the predominant response. It is speculated that cyclic AMP in many cases may be a second messenger for dir

Conscientious

Regulation of Cardiac Contractile Activity by Cyclic Nucleotidescyclic AMP-dependent protein kinase. Cyclic AMP, by stimulating a cyclic AMP-dependent protein kinase, appears also to increase active Ca. transport into the sarcoplasmic reticulum and Ca. efflux from this intracellular membrane structure. Both of these effects are related to phosphorylation of phos

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The Role of Cyclic Nucleotides in the Nervous System indirectly via a regulatory action on release processes. Cyclic nucleotides appear to act by activating a class of cyclic AMP and cyclic GMP-dependent protein kinases. While the functions of some of the endogenous substrates for these kinases, and the effect of phosphorylation are largely unknown,

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Conjuction

Parathyroid Hormone, Bone and Cyclic AMPnction, and that PTH, at least, alters osteoblastic function. The problem is further complicated by the fact that there are both immediate (early) and long term (late) effects of these hormones upon bone cell function, and bone cell number. Furthermore, since some studies are carried out in vivo in

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The Role of Cyclic Nucleotides and Calcium in Adrenocortical Functionons. Recent studies have indicated a preferential output of deoxycorticosterone by zona reticularis cells as compared with zona fasciculata cells (Bell et al. 1979; see also J. Tait and Tait 1979 and J. Tait et al. 1980 a for review)..Various cell preparations have been used in studies of the intrac

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