Titlebook: Current Hypotheses and Research Milestones in Alzheimer‘s Disease; George Perry,Ricardo B. Maccioni Book 2009 Springer-Verlag US 2009 Alzh

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Monique Frize,Claire Deschênes,Ruby Heap the diversity of the earliest events that trigger neurodegeneration, and that eventually result in senile plaques (SP) and neurofibrillary tangles (NFTs). The original version of the most commonly held amyloid hypothesis rests on the concept that amyloid-β (Aβ). self-polymerizes over many years to

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Women Vloggers, Cultures & Natures, Parkinson’s, Huntington’s, and prion diseases), as well as several systemic amyloidosis. Among them, prion disease are the only one known to be infectious. Current evidence shows that the infectious agent in prion diseases is the misfolded protein and that the molecular mechanisms responsible for

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What Have We Learned from the Tau Hypothesis?ss, neuroinflammation, immune deregulation, impairment of neuronal-glial communication, and neurotoxic agents appear to be the major factors triggering neuronal degeneration, and the balance among these seems to vary from patient to patient. Although diverse, these factors induce deleterious signali