Titlebook: Current Directions in Insulin-Like Growth Factor Research; Derek Roith,Mohan K. Raizada Book 1993 The Editor(s) (if applicable) and The Au

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Current Directions in Insulin-Like Growth Factor Research978-1-4615-2988-0Series ISSN 0065-2598 Series E-ISSN 2214-8019

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https://doi.org/10.1007/978-3-031-18258-7ligands (IGF-I, IGF-II and insulin),. three receptors (type 1 and type 2 IGF receptors and insulin receptors). and six distinct, but structurally related binding proteins (IGFBP-1 to IGFBP-6).. The physiological interactions among these components of the IGF system are not completely understood, although they have all been cloned and sequenced..

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Arash Dahi Taleghani,Livio Santosmolecular corollary of this has also been demonstrated for the majority of the genes studied: Both copies of each autosomal gene are equivalently expressed at the mRNA level, regardless of the parent from which each was derived.

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The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcriptiontative role of IGF-I as a progression factor in the cell cycle.. Recent studies have shown that overexpression of the IGF-I-R in a fibroblast cell line abrogates all requirements for exogenous growth factors, suggesting that this receptor does, in fact, mediate a central mechanism in the cell cycle..

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0065-2598 igands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, ther