Titlebook: Current Directions in Insulin-Like Growth Factor Research; Derek Roith,Mohan K. Raizada Book 1993 The Editor(s) (if applicable) and The Au

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https://doi.org/10.1007/978-3-031-18545-8evelopment and in the control of both normal and abnormal growth (for reviews, see Werner et al., 1991 and Lowe, 1991). The importance of the IGF-1 receptor in development is especially supported by the seminal experiments of Efstratiadis and co-workers (DeChiara et al., 1990, and personal communica

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and the Reconfiguration of Civil Societych and Schlessinger, 1990). The structure of the insulin receptor, defined using recombinant DNA techniques, exhibits a high degree of overall similarity with the receptor for the structurally related insulin-like growth factor (IGF), IGF-I (for review, see Czech, 1989). These heterotetrameric glyco

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https://doi.org/10.1007/978-3-031-18888-6via binding to specific high affinity receptors on the plasma membrane of target cells. Similar to these growth factors, the receptors for insulin and IGF-1 share a high degree of structural and functional properties.. Both these receptors are classified as Type I receptors being composed of two a s

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and the Reconfiguration of Civil Societyt cell types. The receptors show considerable similarity in primary sequence within a common disulphide linked (αβ)2 subunit structure. The insulin receptor-related receptor (IRR), a third member of this receptor family for which a ligand has yet to be identified, apparently has a much more restrict