Titlebook: Crystallographic and Modeling Methods in Molecular Design; Charles E. Bugg,Steven E. Ealick Book 1990 Springer-Verlag New York, Inc. 1990

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of molecular dynamics in NMR structural refinement, in understanding loop motion and catalytic activity of mutants in triose phosphate isomerase and in the application of free energy perturbation methods in protein design, site-specific mutagenesis and in thermal stability.

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A dodecamers has been solved and refined by single crystal X-ray diffraction analysis. In these complexes, the drug molecules bind to the central AT segment (4–6 base pairs long) in the narrow minor groove of the dodecamer B-DNA double helix. The stabilizing forces between the drugs and DNAs are pro

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tient may suffer from more than one form of epilepsy. In addition, not all anticonvulsant drugs are effective against all types of seizure. There are two main classes of epileptic seizure, partial and generalized. These two classes of seizure are initiated differently: partial seizures begin at a lo

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