Titlebook: Crohn‘s Disease and Ulcerative Colitis; From Epidemiology an Daniel C. Baumgart Book 2017Latest edition Springer International Publishing A

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Immunobiology of T-Cells in Inflammatory Bowel Disease and regulatory T cells, are generated locally and function in the intestinal mucosa. Effector T cells, which mediate inflammation, can be classified by unique cytokine expression signatures. Crohn’s disease (CD) has been associated with Th1 and Th17 cytokine secretion, whereas Th2 cytokines have be

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Immunobiology of B Cells in Inflammatory Bowel Diseaseinflammatory bowel disease (IBD) has not been determined. The pathogenic role of antibodies has been suggested by the frequent presence of circulating antibodies to self- and microbial antigens in IBD. Antibodies could also regulate inflammation through Fc receptors of IgG. Although most studies per

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Immune Functions of Epithelial Cells in Inflammatory Bowel Diseasestem and the external environment. While carrying out nutrient absorption functions, mucosal surfaces of the alimentary tract are constantly exposed on the luminal surface to microbes and foreign antigens. For years, the sole role ascribed to the epithelium was acting as a highly selective barrier.

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Mouse Models of Chronic Intestinal Inflammation: Characterization and Use in Pharmacological Interverent diseases as well as to assess the efficacy and toxicity of different therapeutic agents. Retrospective analyses of numerous . intervention studies using mouse models of acute and chronic inflammatory diseases reveal a generalized failure to translate promising interventions or therapeutics into

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Stem Cells and Organoids to Study Epithelial Cell Biology in IBDe. The identification of Lgr5-expressing adult intestinal stem cells was a seminal advance in the establishment of adult intestinal organoids (also called enteroids), which can be derived from patient biopsies and used to model human diseases. A second type of intestinal organoid that is generated v