Titlebook: Critical Issues in Head and Neck Oncology; Key Concepts from th Jan B. Vermorken,Volker Budach,Brian O‘Sullivan Book 2018 Springer Nature S

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The Role of Vaccination in the Prevention of Head and Neck Cancernes on premalignant head and neck lesions is not measurable, but it is universally believed that HPV vaccines are able to prevent a considerable number of oropharyngeal cancers and a small proportion of oral cavity and larynx cancers. Recent studies on the effect of HPV vaccination on oral HPV infec

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Oncogenomics/Proteomics of Head and Neck Cancerlops in a single tissue in a relatively small anatomical region, it is remarkably heterogeneous. At present two separate disease entities are distinguished: HNSCCs caused by human papillomavirus (HPV) infection and those that do not contain HPV. However, multiple high-throughput biomolecular methods

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Targeted Next-Generation Sequencing in Head and Neck Cancerct, have led to a largely increased knowledge of the molecular pathways that underlie cancer. The integration of high-throughput sequencing, known more commonly as “next-generation” sequencing (NGS), into standard clinical practice has enabled more targeted treatment of various malignancies based on

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Homologous Recombination Repair Function as a Predictor of Treatment Responseh, it is essential to maintenance of normal tissue homeostasis. HRR function is very frequently disrupted in cancer cells and may serve both as a potential biomarker of response to standard-of-care treatments (e.g. radiotherapy/chemoradiotherapy) and a target for small molecule inhibitors that may m

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Surgical Management of Oral Cavity Canceretection of oral cancer remains very important and efforts should be directed towards this. Adequate surgical removal using modern techniques, appropriate neck management and contemporary use of soft tissue and bone reconstruction yields the best results. Newer developments include sentinel node bio

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Reconstruction in the Oral Cavity: When and Howity is surgical resection, but without reconstruction, the loss of anatomical structures within the mouth leads to substantial reduction in the patient’s quality of life. The advent of microvascular free tissue transfer has greatly improved aesthetic and functional outcomes, and the use of osseous f

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Induction Chemotherapy: Does It Have a Place in Oral Cavity Cancer?vestigated induction chemotherapy followed by surgery in patients with squamous cell oral cavity cancers. These two trials did not demonstrate the superiority of the induction arms. However, patients with a clinical response or favorable pathologic response had a better outcome compared with patient