Titlebook: Corona- and Related Viruses; Current Concepts in Pierre J. Talbot,Gary A. Levy Book 1995 Springer Science+Business Media New York 1995 Ant

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Biological and Molecular Differentiation Between Coronaviruses Associated with Neonatal Calf Diarrhontery (WD). The formation of polykaryons in the infected cell cultures was found to be dependent on the presence of trypsin in the medium. Virus identification was confirmed by indirect immunofluorescence and indirect protein A-gold immunoelectron microscopy using rabbit hyperimmune serum, as well a

MAUVE

Molecular Differentiation of Transmissible Gastroenteritis Virus and Porcine Respiratory Coronavirusnd tissue tropism have been observed among porcine coronaviruses. Although porcine respiratory coronavirus (PRCV) is antigenically similar but not identical to TGEV isolates, these respiratory coronaviruses differ markedly in pathogenicity and tissue tropism compared to TGEV isolates. Using a revers

antiandrogen

Organ Specific Endothelial Cell Heterogeneity Influences Differential Replication and Cytopathogenicectively. Studies on the mechanisms involved in organ specific infection of mouse hepatitis virus (MHV) have focused on several factors such as dose, route of administration, age and strain of experimental animals.. Another potential mechanism for regulation of tissue specific spread of virus is the

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Genomic Regions Associated with Neurotropism Identified in MHV by RNA-RNA Recombinationed by Dr. Michael Lai) were used to map genetic determinants of viral neurotropism and demyelination. Following intracerebral (IC) inoculation of 4-week old C57B1/6 mice, 1LD50 of MHV-A59 produced acute meningoencephalitis and hepatitis, and subsequently chronic CNS demyelinating disease. IC inocula

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Spread of MHV-JHM from Nasal Cavity to White Matter of Spinal Cordtion several weeks after inoculation. Virus must spread from the site of inoculation, the nasal cavity, to the site of disease, the white matter of the spinal cord. It has been shown previously that after intranasal inoculation, virus enters the brain via the olfactory nerve and spreads to infect ma

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In Vitro Interaction of Coronaviruses with Primate and Human Brain Microvascular Endothelial CellsRNAs could be detected up to 72 hours post-infection, primate cells were abortively infected and neither virus caused cytopathology. Human cells were non-permissive for JHM but permissive for 229E replication; peak production of progeny 229E and observable cytopathic effects occurred approximately 2

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Treatment of Resistant A/J Mice with Methylprednisolone (MP) Results in Loss of Resistance to Murinehe lethal effects of MHV-3 infection. Previous studies have implicated macrophage activation with production of a unique macrophage prothrombinase (PCA) and lymphocyte cytokine secretion in the pathogenesis of MHV-3 susceptibility and have demonstrated that immunosuppression induces susceptibility i