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Titlebook: Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C?H Bonds; Stacey L. McDonald Book 2016 Springer International Publishing Switzerl

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書(shū)目名稱Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C?H Bonds
編輯Stacey L. McDonald
視頻videohttp://file.papertrans.cn/239/238178/238178.mp4
概述Nominated as an outstanding PhD thesis by Duke University.Provides a comprehensive review of electrophilic aminations using O-benzoylhydroxylamines.Presents results which are relevant for medicinal ch
叢書(shū)名稱Springer Theses
圖書(shū)封面Titlebook: Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C?H Bonds;  Stacey L. McDonald Book 2016 Springer International Publishing Switzerl
描述.This thesis reports the latest developments in the direct amination of various C?H bonds using an H?Zn exchange/electrophilic amination strategy.? McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. ..The material outlined in this book shows how McDonald achieved C?H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. ..McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.?.
出版日期Book 2016
關(guān)鍵詞Electrophilic Amination; Aryl Amines; Copper-Catalyzed Amination; C–H Functionalization; C–N Bond Format
版次1
doihttps://doi.org/10.1007/978-3-319-38878-6
isbn_softcover978-3-319-81767-5
isbn_ebook978-3-319-38878-6Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer International Publishing Switzerland 2016
The information of publication is updating

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,Selective α-Amination and α-Acylation of Esters and Amides via Dual Reactivity of ,-Acylhydroxylamitive aminating and acylating reagent. Treatment of zinc enolates with .-acylhydroxylamines provides solely 1,3-dicarbonyl compounds under mild conditions. Introduction of a copper catalyst into the system shifts the reactivity entirely, yielding a-amination products exclusively.
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https://doi.org/10.1007/978-1-4020-9902-1range of heteroaromatic and aromatic amines including those previously inaccessible using C–H amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.
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Book 2016Donald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. ..The material outlined in this book shows how McDonald achieved C?H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corres
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,Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C–H Zincation,range of heteroaromatic and aromatic amines including those previously inaccessible using C–H amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.
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