Titlebook: Cooperation of Liver Cells in Health and Disease; Zbigniew Kmie? Book 2001 The Editor(s) (if applicable) and The Author(s), under exclusiv

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is the general term for a class of lipopolysaccharide (LPS) molecules located in the outer cell membrane of gram-negative bacteria. Endotoxin constitutes physiological constituent of portal-venous blood (Jacob et al. 1977), and under normal conditions, in contrast to extrahepatic tissues, it does n

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s chemicals. Liver fibrosis is characterized by both quantitative and qualitative changes in the composition and distribution of extracellular matrix (ECM) that are reflected by a three- to fivefold net increase of ECM and replacement of low-density basement membrane-like material by interstitial ty

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ocytes and non-parenchymal liver cells, and between different types of nonparenchymal cells, play an important role in liver functions under both normal and pathological situations. The expression of many intercellular mediators has been shown to be regulated by other molecules released by various t

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total liver volume and perform the majority of numerous liver functions, nonparenchymal liver cells, which contribute only 6.5% to the liver volume, but 40% to the total number of liver cells, are localized in the sinusoidal compartment of the tissue. The walls of hepatic sinusoid are lined by three

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Advances in Anatomy, Embryology and Cell Biologyhttp://image.papertrans.cn/c/image/237915.jpg

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Introduction — Morphology of the Liver Lobulec structure of the mammalian liver has been recognized relatively early. In 1833, Kiernan proposed that lobes of the pig liver organized around main branches of the portal vein were built up of small polyhedron morphological units of parenchyma, called lobules, with boundaries made of connective tis

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Hepatic Stellate Cellssinusoidally, always attached to the sinusoidal capillaries and also to the parenchymal cells (Kupffer 1876, cited by Wake 1980). Although originally Kupffer thought that these cells belonged to perivascular cells of connective tissue, after 20 years he changed his mind and suggested that the cells