Titlebook: Cooperation of Liver Cells in Health and Disease; Zbigniew Kmie? Book 2001 The Editor(s) (if applicable) and The Author(s), under exclusiv

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a regular basement membrane, and are often embraced by the cytoplasmic processes of underlying hepatic stellate cells. SEC constitute an important filtration barrier between macromolecules and blood cells present in the sinusoidal lumen and hepatocytes that prevents their direct contact, and determ

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Cpap155

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orptive phase (glucogenesis), and to release glucose in the postprandial period as a result of glycogenolysis and de novo glucose synthesis from noncarbohydrate substrates, such as lactate, glycerol, or amino acids, i.e., gluconeogenesis. Hepatic glucose production, necessary for survival in the fas

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liferation represents one of their main characteristics. Both parenchymal and nonparenchymal liver cells are not only targets but also sources of some important growth factors, and of their respective binding proteins. Many growth factors produced by liver cells act not only on extrahepatic cells, b

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ed at the elucidation of the pathogenesis of portal hypertension, a life-threatening complication of liver fibrosis and cirrhosis. Apart from regulatory mechanisms operating at the level of pre- and postcapillary vessels, it was shown in vivo that sinusoids constrict in a graded and reversible manne