Titlebook: Controlled Clinical Trials in Neurological Disease; Roger J. Porter,Bruce S. Schoenberg Book 1990 Kluwer Academic Publishers 1990 Alzheime

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Perspective of the Insurance Industryfor about half of the health insurance market. Such carriers have no stockholders, pay no dividends, and must use their resources to pay for care and the administrative costs of the insurance process. Thus, it would seem easy for an insurer to accommodate the demands of an expanding health armamentarium without undue conflict. It is not.

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Statistical and Epidemiological Considerationsis often tedious to make and may require an extended period of patient observation. Also, the etiology and natural history of neurologic diseases are often obscure. Finally, for those patients with a diagnosed neurologic disease, the clinical course of the condition, including outcome, can be variable and difficult to measure.

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0924-8935 vention, is an im- portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians lea

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Vorposten der Gesundheitspflegeegal and regulatory foundation of the Agency’s decision-making process. For this reason, it is important to describe in some detail the relevant law and regulations that the Agency is charged with enforcing.

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Initial Statistical Considerationsicine. Clearly, however, the comparative clinical experiment dates from much earlier; the Book of Daniel describes a comparative trial of two diets [2]. Several authors have reviewed the development of the modern clinical investigation from a statistical viewpoint [3, 4].

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Perspective of the Food and Drug Administrationegal and regulatory foundation of the Agency’s decision-making process. For this reason, it is important to describe in some detail the relevant law and regulations that the Agency is charged with enforcing.