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Titlebook: Continuous Dopaminergic Stimulation in Parkinson’s Disease; Proceedings of the W J. A. Obeso,R. Horowski,C. D. Marsden Conference proceedin

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樓主: VER
41#
發(fā)表于 2025-3-28 16:59:20 | 只看該作者
Chronic s.c. Lisuride in Parkinson’s disease — motorperformance and avoidance of psychiatric side ef L-deprenyl. L-Dopa infusions are efficient, but not applicable for longer use. S. c.-Lisuride-infusions reduce markedly motor-response fluctuations, dystonias and hyperkinesias, but bear the risk of inducing confusion or even psychosis. In patients with coexisting response fluctuations and psychiat
42#
發(fā)表于 2025-3-28 22:00:50 | 只看該作者
Continuous subcutaneous lisuride infusions in Parkinson’s diseasewith continuous (24 hour) subuctaneous lisuride infusions together with a reduced dose of levodopa (plus DDI). An improvement in motor performance was seen in 10 patients, with a mean increase in percentage of waking time spent “on” of 32 per cent (range 13–59 percent). However, adverse effects were
43#
發(fā)表于 2025-3-29 01:32:52 | 只看該作者
A combined regimen of subcutaneous lisuride and oral Madopar HBS in Parkinson’s disease-release form, Madopar HBS, which attenuated fluctuations in patients with end-of-dose impairment, but achieved only moderate improvement in patients with on-off phenomena..In a second phase of the trial, 4 parkinsonians exhibiting the most severe fluctuations of mobility and the poorest response to
44#
發(fā)表于 2025-3-29 03:07:06 | 只看該作者
45#
發(fā)表于 2025-3-29 10:48:25 | 只看該作者
Lisuride infusion pump in Parkinson’s disease. A report of two cases treated with Lisuride by means of a portable subcutaneous infusion pump are reported..Results obtained show significant improvement in disability through a net increase in the number of hours spent “on”. Dyskinesias remained unmodified. Limiting psychiatric side effects were observed in one of the
46#
發(fā)表于 2025-3-29 11:23:33 | 只看該作者
47#
發(fā)表于 2025-3-29 17:49:23 | 只看該作者
48#
發(fā)表于 2025-3-29 22:52:49 | 只看該作者
49#
發(fā)表于 2025-3-30 02:59:17 | 只看該作者
50#
發(fā)表于 2025-3-30 06:59:02 | 只看該作者
Effect of chronic subcutaneous minipump infusion of lisuride upon locomotor activity of ratscomotor activity was measured at 5 hours, 1, 7 and 14 days after implantation. Thereafter the minipumps were removed and 1, 7 and 21 days later the locomotor activity was recorded after a subcutaneous challenge dose of lisuride 0.1 mg/kg. In the course of continuous infusion the lisuride-treated rat
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