Titlebook: Conditional Mutagenesis: An Approach to Disease Models; Robert Feil,Daniel Metzger Book 2007 Springer-Verlag Berlin Heidelberg 2007 Chromo

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Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Threshrm line gene inactivation are instrumental in establishing the importance of such genes in vivo, distortion of embryonic development or multiple body systems often preclude detailed functional studies. To overcome this limitation, DNA recombination systems such as Cre/loxP of bacteriophage P1, have

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Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and contribution of specific genes to brain functions is difficult because the brain is a highly complex organ with multiple neuroanatomical structures, orchestrating virtually every function in the body. Further, higher-order brain functions such as learning and memory simultaneously recruit several s

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Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopand cardiomyopathy. It is caused by severely reduced levels of frataxin, a mitochondrial protein involved in iron-sulfur cluster (ISC) biosynthesis. Mouse models have been important tools in dissecting the steps of pathogenesis in FRDA. Furthermore, animal models that reproduce some of the key events

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Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disordersof human diseases. Both aspects have proven to be of particular importance in the study of lipid-related disorders. Classical approaches to gene inactivation by conventional gene targeting strategies have been successfully applied to generate animal models like the LDL receptor- and the apolipoprote

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Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/c/image/235210.jpg

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QoS Preservation in Web Service Selection,malian genome. The technology, based on the Cre/. system, is used more and more in the scientific community in order to generate new chromosomes carrying deletions, duplications, inversions and translocations in targeted regions of interest. In this review, we will present the basic principle of the