Titlebook: Concepts in Viral Pathogenesis III; Abner Louis Notkins,Michael B. A. Oldstone Book 1989 Springer-Verlag New York Inc. 1989 Viruses.biolog

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Structural Determinants of Serotype Specificity and Host Range in Poliovirushe structure for the architecture, evolution, assembly, and immune recognition of polio and closely related picornaviruses were presented [1]. Since that time, we have solved the structure of the Sabin (attenuated vaccine) strain of type 3 poliovirus (P3/Sabin) [2] and, more recently, of an intertyp

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The Molecular and Functional Basis of Poliovirus Attenuation and Host Rangesearch on the virus was aimed at providing the necessary information on antigenic types, pathogenesis, and immunity so that vaccines could be developed. After two effective vaccines were produced, research on poliovirus turned toward understanding events that occur in infected cells, such as viral R

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Role of Enhancer Regions in Leukemia Induction by Nondefective Murine C Type Retrovirusese often referred to as murine leukemia viruses (MuLVs). Transformation by MuLVs is mediated by the integration of proviruses adjacent to one or more protooncogenes, thus altering the transcriptional regulation of these cellular genes. Tumors result from the clonal or oligoclonal outgrowth of such ce

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Activation of Adenovirus Gene Expressionon units (E1A, E1B,E2, E3, E4, and major late L1) become active very soon after the viral chromosome reaches the nucleus of the infected cell. Several hours later, concomitant with the onset of DNA replication, three late units (IX, IVa2, and major late) are expressed at high levels. Expression of t

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