Titlebook: Concepts in Viral Pathogenesis II; Abner Louis Notkins,Michael B. A. Oldstone Textbook 1986 Springer Science+Business Media New York 1986

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Peter G. Bergmann,Venzo Sabbatatual eradication of a dreaded disease. Because the last natural case of smallpox occurred eight years ago, the need for vaccination is over. Recently, however, the heretical notion that vaccinia virus might be used for immunoprophylaxis of other diseases was suggested [1–4]. Simply stated, by isolat

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The Theory of Donaldson Invariants,cogenes are “activated” and play an important role in carcinogenesis. Most tumors have karyotypic abnormalities [1,2]. In any given tumor, all the cells frequently show the same, or related, alteration, indicating that the cytogenetic change is conferring a selective advantage on the cells carrying

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Topological Aspects of Four-Manifolds,model systems provided by these viruses have proven to be valuable sources of information not only on the mechanisms by which normal cells become malignant, but also on how they grow and differentiate. The acutely transforming retroviruses contain genes, termed ., that are responsible for causing tu

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Some Applications of the ,-plane Integral, for gene control to specific host environments. Although we may be accustomed to analyze viral gene regulation in cultures of cells that are permissive for a given virus or suitable for transfection with cloned gene constructs, in the living organism the virus associates itself with cells that may

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