Titlebook: Computational Systems Biology; Methods and Protocol Tao Huang Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018

NIL

Bioinformatics Analysis for Cell-Free Tumor DNA Sequencing Data, provide comprehensive genetic information of tumor and better overcome the tumor heterogeneity problem comparing to tissue biopsy. Developed in recent years, next-generation sequencing (NGS) is a widely used technology for analyzing ctDNA. Although the technologies of processing ctDNA samples are m

embolus

An Overview of Genome-Wide Association Studies,ween common single-nucleotide polymorphisms (SNPs) and common human diseases such as heart disease, inflammatory bowel disease, type 2 diabetes, and psychiatric disorders. The standard strategy of population-based case-control studies for GWAS is illustrated in this chapter. We provide an overview o

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不遵守

The Reconstruction and Analysis of Gene Regulatory Networks,and their organization in living cells. For this end, gene regulatory networks (GRNs) are constructed to show relationship between biological molecules, in which the vertices of network denote biological molecules and the edges of network present connection between nodes (Strogatz, Nature 410:268–27

headway

Differential Coexpression Network Analysis for Gene Expression Data,n profiling just focuses on the individual genes, and the interactions among genes are ignored, while genes play their roles not by isolations but by interactions with each other. Consequently, gene-to-gene coexpression analysis emerged as a powerful approach to solve the above problems. Then comple

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delta-waves

Largess

Identifying Interactions Between Long Noncoding RNAs and Diseases Based on Computational Methods,NAs (lncRNAs) are the biggest kind of noncoding RNAs with more than 200?nt nucleotides in length. There are increasing evidences showing that lncRNAs play key roles in many biological processes. Therefore, the mutation and dysregulation of lncRNAs have close association with a number of complex huma

HARP

Survey of Computational Approaches for Prediction of DNA-Binding Residues on Protein Surfaces,annotations on proteins. In this chapter, different kinds of computational approaches are briefly introduced to predict DNA-binding residues on surface of DNA-binding proteins, and the merits and limitations of these methods are mainly discussed. This chapter focuses on the structure-based approache

glans-penis

Computational Prediction of Protein O-GlcNAc Modification,mall portion of O-GlcNAcylation sites. Several computational algorithms have been proposed as necessary auxiliary tools to identify potential O-GlcNAcylation sites. This chapter discusses the metrics and procedures used to assess prediction tools and surveys six computational tools for the predictio