Titlebook: Computational Stem Cell Biology; Methods and Protocol Patrick Cahan Book 2019 Springer Science+Business Media, LLC, part of Springer Nature

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Agent-Based Modelling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Nicheion (PFLI) gene circuit in the intestinal crypts. Specifically, techniques for gene circuit-driven hypothesis formation, geometry construction, selection of simulation parameters, and simulation quantification are presented.

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Modeling Cellular Differentiation and Reprogramming with Gene Regulatory Networkso coordinate and maintain the overall gene expression profile observed in a cell is a key question in cellular biology. However, the immense complexity arising due to the scale and the nature of gene-gene interactions often hinders obtaining a global understanding of gene regulation. In this regard,