Titlebook: Computational Modeling of Drugs Against Alzheimer’s Disease; Kunal Roy Book 2023Latest edition The Editor(s) (if applicable) and The Autho

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Carol Swetlik B.A.,Kathleen N. Franco M.D.defined by progressive neuronal death and synaptic loss in the human brain and can be brought on by both genetic and environmental risk factors. The beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the major beta secretase for the generation of amyloid-β peptides in the neurons

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Farah Munir,Sarah Nagle-Yang,Cathleen Cernyent of this ailment. Despite several hurdles have been overcome and several BACE-1 inhibitors progressed to clinical trials, none has reached the market until now. The synergy of ligand- and structure-based molecular modeling tools proved essential to gain a deeper understanding of BACE-1 conformati

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Farah Munir,Sarah Nagle-Yang,Cathleen Cerny, and behavioral changes. Being the most common form of senile dementia, AD can be characterized by the presence of two types of neuropathological hallmarks: neurofibrillary tangles (NFTs) and senile plaques (SP). The phosphorylation of tau is controlled and regulated by a group of kinase and phosph

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Ad J. F. M. Kerkhof,Brian L. Misharaand tau imaging agents can detect early AD pathological processes and subsequent neurodegeneration. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are efficient imaging techniques for the in vivo detection of Alzheimer’s disease pathologies. In the current

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Protective Factors in Suicidal Behavior huge economic as well as societal burden. The markers of oxidative stress have been noted early in AD, which highlight the likely participation of reactive oxygen species (ROS) in the cascade of events that lead to neuronal dysfunction. The mitochondrial enzyme monoamine oxidase (MAO) helps in the

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