Titlebook: Computational Methods in Systems Biology; 15th International C Jér?me Feret,Heinz Koeppl Conference proceedings 2017 Springer International

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Melissa Marques-McEwan,Umit Sezer Bititciitable changes in gene expression not encoded by the DNA sequence. The underlying mechanisms controlling DNA methylation are only partly understood and recently different mechanistic models of enzyme activities responsible for DNA methylation have been proposed. Here we extend existing Hidden Markov

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Jarle Nyberg,Sverre S?rbye Larsenurb. Most of computational methods focus on finding mutations to apply to the initial state in order to control which attractor the cell will reach. However, it has been shown, and is proved in this article, that waiting between the perturbations and using the transient dynamics of the system allow

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https://doi.org/10.1007/978-3-319-99704-9zing sets of models consistent with the available information. In this setting, methods not depending on consideration of every single model in the set are necessary for efficient analysis. Drawing from ideas developed in qualitative differential equation theory, we present an approach to analyze se

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Lean Leadership in Production Ramp-Upk. Each specific model system builds on a knowledge base of rules formalizing local process steps such as post translational modification. The Pathway Logic Assistant (PLA) is a collection of visualization and reasoning tools that allow users to derive specific executable models by specifying of an