Titlebook: Computational Methods in Systems Biology; 12th International C Pedro Mendes,Joseph O. Dada,Kieran Smallbone Conference proceedings 2014 Spr

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Conference proceedings 2014 UK, in November 2014. .The 16 regular papers presented together with 6 poster papers were carefully reviewed and selected from 31 regular and 18 poster submissions. The papers are organized in topical sections on formalisms for modeling biological processes, model inference from experimental data,

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Trace Simplifications Preserving Temporal Logic Formulae with Case Study in a Coupled Model of the C of trace simplifications which are correct to perform for some common temporal logic formulae. We give some general soundness theorems, and apply this approach to period and phase constraints on the circadian clock and the cell cycle. In this application, temporal logic patterns are used to compute

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Exploring the Cellular Objective in Flux Balance Constraint-Based Modelserent classes of optimality criteria and the effect of single (or combinations of) standard constraints in order to improve the predictive power of intracellular flux distribution. These were evaluated to compare predicted fluxes to published experimental .C-labelling fluxomic datasets using two met

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Assessing Patient-Centered Outcomesand it is possible to directly query the network instead with an appropriate tool. For ensuring a good query time, we will rely on a state of the art SAT solver, working on a propositional encoding of ., and enriched with a simple SMT-like solver ensuring . consistency with stoichiometric constraint