Titlebook: Computational Methods for Estimating the Kinetic Parameters of Biological Systems; Quentin Vanhaelen Book 2022 Springer Science+Business M

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Jean-Pierre Antoine,Romain Murenzi low enzyme concentration. Furthermore, even when this condition is satisfied, parameter estimation is often imprecise due to the parameter identifiability issue. To overcome these limitations of the canonical approach to enzyme kinetics, we developed a Bayesian approach based on a modified form of

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Subcellular Basis of Contractile Failureonal behavior that arises from varying concentrations of the cellular components over time. Here, we describe a computational tuning framework to facilitate both the selection of kinetic parameters for these models and its estimation from experimental data. On the one hand, the tuning framework uses

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Subcellular Basis of Contractile Failurelucidate intracellular regulation. To construct such quantitative and predictive models of intracellular interactions, unknown parameters need to be estimated. Most of biological data are expressed in relative or arbitrary units, raising the question of how to compare model simulations with data. It

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Craig T. January,Harry A. Fozzardf enzymes today, as they are now largely produced using recombinant technology, or can even be synthesized from scratch. Studies of the three-dimensional structures of enzymes can provide answers to many questions, but the kinetics of enzymatic reactions is the only method that can lead to better un

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Kiyotaka Hitomi,Norihiro Tsukagoshi of the transient variations in localized H.O. pools during signaling events and how these variations impact redox switches present in the cell remain elusive. A canonical model with two chemical reactions comprising the oxidation/reduction cycle of a redox switch is described. The model is dimensio

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The Mitochondrial Translation System,s in target-based systems. This technique has become a powerful tool in medicinal chemistry for the identification of hit molecules. The recent developments in target-based systems have played a major role in the creation of libraries of compounds, and it has also been widely applied for the design

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Hilton H. Mollenhauer,D. James Morrémentary way to investigate these catalytic reactions. Experimental assay frequently does not allow an unequivocal answer to the factors controlling the reaction mechanism. On the other hand, the theoretical experiments provide a precise understanding of the molecular-level steps involved in catalyti

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