Titlebook: Computational Genome Analysis; An Introduction Richard C. Deonier,Michael S. Waterman,Simon Tavar Textbook 2005 Springer-Verlag New York 20

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Sequence Alignment,of functionally conserved sequences (e.g., DNA sequences controlling gene expression). Finally, such comparisons between humans and other species may identify corresponding genes in model organisms, which can be genetically manipulated to develop models for human diseases.

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Signals in DNA, binding in the thermodynamic sense. This may be strong binding, as in the case of repressors binding to operators, or binding may be transient, as with restriction endonucleases. Examples of common signals in DNA are:

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Similarity, Distance, and Clustering,chapter and will say a little more at the end of this chapter. For more extensive discussions of clustering and classification, see Dunn and Everitt (1982), Everitt and Dunn (2001), and Johnson and Wichern (2002).

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Textbook 2005uses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book is appropriate for a one-semester course for advanced undergraduate or beginning graduate students, and it can also intro

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