Titlebook: Computational Genetics and Genomics; Tools for Understand Gary Peltz Book 2005 Humana Press 2005 Haplotype.Radiologieinformationssystem.SNP

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HLA Polymorphism and Disease Susceptibilityhe function of the immune system (.). The HLA class I (HLA-A, B, and C) and class II (DRB1, DQB1, DPB1, and DQA1) loci encode cell surface heterodimeric proteins that bind antigenic peptides and are the most polymorphic genes in the human genome (. Fig. 1 for HLA region map). Moreover, most of this

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Murine Models of Osteoporosisnerability to developing osteoporosis is inherited (.,.). Almost certainly, the development of osteoporosis will be found to involve a complex interplay between both genetic and environmental factors that are difficult to control in complex populations.

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HLA Polymorphism and Disease Susceptibilityhat these polymorphic sequences have been subjected to balancing selection (., .). Analyses of allele frequency distributions (.) in various human populations have also supported the action of balancing selection for all HLA loci, with the exception of DPB1 (.). However, the Ewens-Watterson test (.)

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Book 2005enetic basis for susceptibility to disease. Although this very broad topic is addressed in many other books and journal articles, Computational Genetics and Genomics: Tools for Understanding Disease focuses on methods used for analyzing mouse genetic models of biomedically - portant traits. This vol