| 書目名稱 | Computational Biology of Transcription Factor Binding | | 編輯 | Istvan Ladunga | | 視頻video | http://file.papertrans.cn/233/232135/232135.mp4 | | 概述 | Guides scientists of all disciplines through the jungle of regulatory regions, ChIP-seq, about 200 motif discovery tools and others.Includes vital tricks-of-the-trade from experts well-versed in the t | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | Transcriptional regulation controls the basic processes of life. Its complex, dynamic, and hierarchical networks control the momentary availability of messenger RNAs for protein synthesis. Transcriptional regulation is key to cell division, development, tissue differen- ation, and cancer as discussed in Chapters 1 and 2. We have witnessed rapid, major developments at the intersection of computational biology, experimental technology, and statistics. A decade ago, researches were struggling with notoriously challenging predictions of isolated binding sites from low-throughput experiments. Now we can accurately predict cis-regulatory modules, conserved cl- ters of binding sites (Chapters 13 and 15), partly based on high-throughput ch- matin immunoprecipitation experiments in which tens of millions of DNA segments are sequenced by massively parallel, next-generation sequencers (ChIP-seq, Chapters 9, 10, and 11). These spectacular developments have allowed for the genome-wide mappings of tens of thousands of transcription factor binding sites in yeast, bacteria, mammals, insects, worms, and plants. Please also note the no less spectacular failures in many laboratories around the world. | | 出版日期 | Book 2010 | | 關(guān)鍵詞 | Annotation; ChIP-seq; Genome browsers; Motif discovery tools; Promoter; Statistics; Transcriptional regula | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60761-854-6 | | isbn_softcover | 978-1-4939-6166-5 | | isbn_ebook | 978-1-60761-854-6Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science+Business Media, LLC 2010 |
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