| 書(shū)目名稱(chēng) | Computational Approaches to Biochemical Reactivity |
| 編輯 | Gábor Náray-Szabó,Arieh Warshel |
| 視頻video | http://file.papertrans.cn/233/232107/232107.mp4 |
| 叢書(shū)名稱(chēng) | Understanding Chemical Reactivity |
| 圖書(shū)封面 |  |
| 描述 | A quantitative description of the action of enzymes and other biological systems is both a challenge and a fundamental requirement for further progress in our und- standing of biochemical processes. This can help in practical design of new drugs and in the development of artificial enzymes as well as in fundamental understanding of the factors that control the activity of biological systems. Structural and biochemical st- ies have yielded major insights about the action of biological molecules and the mechanism of enzymatic reactions. However it is not entirely clear how to use this - portant information in a consistent and quantitative analysis of the factors that are - sponsible for rate acceleration in enzyme active sites. The problem is associated with the fact that reaction rates are determined by energetics (i. e. activation energies) and the available experimental methods by themselves cannot provide a correlation - tween structure and energy. Even mutations of specific active site residues, which are extremely useful, cannot tell us about the totality of the interaction between the active site and the substrate. In fact, short of inventing experiments that allow one to meas |
| 出版日期 | Book 2002 |
| 關(guān)鍵詞 | biology; biophysics; catalysis; enzyme; enzymes; mechanics; protein; proteins; structural biology |
| 版次 | 1 |
| doi | https://doi.org/10.1007/0-306-46934-0 |
| isbn_softcover | 978-1-4020-0415-5 |
| isbn_ebook | 978-0-306-46934-3 |
| copyright | Springer Science+Business Media Dordrecht 2002 |
|Archiver|手機(jī)版|小黑屋|
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