Titlebook: Complex Systems and Computational Biology Approaches to Acute Inflammation; A Framework for Mode Yoram Vodovotz,Gary An Book 2021Latest edi

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Book 2021Latest editionems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing

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recognizable phenotypes.Addresses the fundamental role of in.This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammat

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Complex Systems and Computational Biology Approaches to Acute InflammationA Framework for Mode

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Book 2021Latest editionecision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained..By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology

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An Overview of the Translational Dilemma and the Need for Model-Based Precision Medicine fore. These methods, while representing a step forward from the reductionist paradigm they are supplanting, also suffer from various pitfalls. We suggest that mechanistically oriented complex systems and computational biology methods and approaches have advanced sufficiently to allow for knowledge

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Integrating Data-Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Traumar indirect positive feedback loops that control switching behavior between beneficial and detrimental inflammatory responses, with the former being self-resolving while the latter are self-sustaining, ultimately leading to multiple organ dysfunction and death. Self-resolving inflammation may occur w

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Therapeutics as Control: Model-Based Control Discovery for Sepsis treat complex diseases. Mechanistic mathematical and computational models, with their roots in optimization and control theory, play a critical role in discovering modalities of control. Though success relies heavily on sufficiently detailed mechanistic models for which development, calibration, an