Titlebook: Complement; Hans J. Müller-Eberhard,Peter A. Miescher Book 1985 Springer-Verlag Berlin Heidelberg 1985 Komplement.bacteria.blood.genetics.

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Zusammenfassung der Ergebnisse,ff’s laboratory, on the restoration of the hemolytic properties of a heated antiserum directed against red cells, paved the way for investigations undertaken by Ehrlich and Morgenroth around the turn of the century. They demonstrated that not antibody alone but an additional factor present was respo

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Adjourn

Introduction and OverviewThese insights emanated from the biochemical investigation of the proteins, their reaction products, and cellular receptors, and from the study of genetic deficiencies in humans and the design and exploration of experimental disease models.

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Structure and Expression of the C3 Gene defective genes, the molecular basis of these deficiencies may be determined. Third, the biochemical properties of the C3 protein and its peptide derivatives and the physiologic effects of their interactions with other complement proteins, regulatory proteins, and cellular receptors must be underst

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The ,-Cys-,-Glu Thiolester Bond in Human C3, C4, and ,,-Macroglobulinhains, . and ., with respective molecular weights of 115 000 and 75 000. Cleavage of C3 by the classical pathway convertase . also results in the formation of two fragments. Again, a vasoactive peptide (C3a) is removed from the amino end of the .-chain leaving a disulfide-bridged protein (C3b), havi

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Initiation of Complement Activationhis similarity, however, the two pathways show fascinating differences in the strategies that are employed in the generation of their products, and in this chapter the initiation mechanisms of the two pathways are to be compared and contrasted.

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The First Component of Human Complement (C1): Activation and Controliator of the classical complement pathway, but also since it is the most readily defined and easily studied mediator of immunoglobulin function. Furthermore, C1 in itself is an intriguing biochemical model involving specific protein-protein interactions, induced conformational changes, and activatio