Titlebook: Combinatorial Chemistry in Biology; Michael Famulok,Ernst-L. Winnacker,Chi-Huey Wong Book 1999 The Editor(s) (if applicable) and The Autho

Left-Atrium

,Antigen Sequence- and Library-Based Mapping of Linear and Discontinuous Protein—Protein-Interactionrecognition events. The application of these positionally addressable peptide libraries include investigating protein/protein (literature cited throughout the text), protein/DNA (. et al. 1993; . et al. 1998) and protein/metal interactions (. et al. 1995). In addition, substrate specificities of kin

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Conflict

Evolutionary Approaches to Protein Engineering,od principles towards achieving a prespecified goal. Designed novel functions of proteins remain largely beyond our capabilities, despite intense efforts of numerous research groups in academia and industry. But we are trying, and the last few years have seen a rapid growth in the number of reports

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Phage Display of Combinatorial Peptide and Protein Libraries and Their Applications in Biology and years. In particular, phage display has become one of the major techniques for the use of combinatorial peptide and protein libraries. The reasons for the success of phage display are, at least, threefold: (1) phage display of combinatorial libraries creates a direct link between phenotype (the sele

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In Vitro Selection Methods for Screening of Peptide and Protein Libraries,therefore a focus of much of current biochemical research and the prerequisite for most pharmaceutical applications. Despite great progress, computational methods have generally not produced the accuracy required for “designing” mutations which improve a function such as binding or stability. Over t