Titlebook: Cochlear Mechanisms: Structure, Function, and Models; J. P. Wilson,D. T. Kemp Book 1989 Springer Science+Business Media New York 1989 Tinn

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ed an opportune time to bring together the leading workers in these various areas, to take stock of the whole field and to stimulate further progress. This book represents the proceedings of a NATO ARW on the Mechanics of Hearing held at the University of Keele, 3-8 July, 1988. The conception of the meeting o978-1-4684-5642-4978-1-4684-5640-0

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Structural Organization of the Mammalian Auditory Hair Cells in Relation to Micromechanicsrating the otoacoustic emission and tuning of the auditory sensory response by exerting influence on the micromechanical environment of the inner hair cell stereociliary bundles. Thus, motile activity of the outer hair cell may have a direct bearing on the micromechanics of the cochlea. This paper i

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Observations on the Cytoskeleton and Related Structures of Mammalian Cochlear Hair Cells of the two cell types and related to motility as a consequence, e.g., the pillars which link the subsurface cistern to the plasmalemma (Flock et al., 1986). Other structures which occur in both OHCs and IHCs have been suggested to underly the process of transduction itself, e.g. the tip links on st

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Aminoglycoside Antibiotics and Lectins Cause Irreversible Increases in the Stiffness of Cochlear Hai with the phosphoinositide second messenger system (Schacht 1979). We have recently developed an organotypic culture system of the neonatal mouse cochlea (Russell, Richardson and Cody 1986, Russell and Richardson 1987), which can be used to directly investigate the effects that aminoglycosides have

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Outer Hair Cells Possess Acetylcholine Receptors and Produce Motile Responses in the Organ of Cortiof actin and myosin is the molecular basis of Ca./ATP-dependend slow motile responses of OHCs (Zenner, 1988). A direct extrapolation, however, from these in vitro results to the conditions in the organ of Corti (OC) is rather dubious. Furthermore, the control mechanisms of OHC motility have not been

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