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Titlebook: Co-signal Molecules in T Cell Activation; Immune Regulation in Miyuki Azuma,Hideo Yagita Book 2019 Springer Nature Singapore Pte Ltd. 2019

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書目名稱Co-signal Molecules in T Cell Activation
副標(biāo)題Immune Regulation in
編輯Miyuki Azuma,Hideo Yagita
視頻videohttp://file.papertrans.cn/229/228622/228622.mp4
概述Explains the basic concepts and roles of co-signal molecules.Discusses applied and clinical studies using co-stimulation mechanisms.Presents a variety of potential therapeutic applications
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Co-signal Molecules in T Cell Activation; Immune Regulation in Miyuki Azuma,Hideo Yagita Book 2019 Springer Nature Singapore Pte Ltd. 2019
描述This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated..Co-signal Molecules in?T Cell Activation?.will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.? ?.
出版日期Book 2019
關(guān)鍵詞Costimulation; Coinhibition; Immune Regulation; CD28; TNF-TNFR; T lymphocytes; Cancer Immunotherapy
版次1
doihttps://doi.org/10.1007/978-981-32-9717-3
isbn_softcover978-981-32-9719-7
isbn_ebook978-981-32-9717-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightSpringer Nature Singapore Pte Ltd. 2019
The information of publication is updating

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Molecular Dynamics of Co-signal Molecules in T-Cell Activationgger the full activation signal. Co-stimulation receptors also accumulate, mostly at the TCR-MC, and induce signals that positively and negatively modulate the direction and magnitude of T-cell activation. CD28 initially colocalizes with the TCR-MC but then migrates to a distinct region of the cSMAC
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