Titlebook: Clinically Relevant Resistance in Cancer Chemotherapy; Borje Andersson,David Murray Book 2002 Springer Science+Business Media New York 200

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Introduction: The Present State of Affairs effects on biological systems. A summary of these early studies by Philips Philips. is of historical interest; it also serves as a model description of cancer drug development based upon evaluation of molecules observed to have antitumor effects as a result of empiric observation and congener synthesis

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0927-3042 as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.978-1-4613-5428-4978-1-4615-1173-1Series ISSN 0927-3042 Series E-ISSN 2509-8497

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https://doi.org/10.1007/978-1-349-26446-9le. The relative cell survival after a six month course of adjuvant chemotherapy for breast cancer has been estimated to be as high as 10. or even greater.. This failure to eradicate all tumor cells has commonly been attributed to the intrinsic resistance of tumor cells to chemotherapy, and the vast

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Recycling as a Source of Regeneration,istant to bis-chloroethyl nitrosourea (BCNU) display a high incidence of increased activity of the protein 0.- alkylguanine DNA alkyltransferase (AGT) which removes mono-alkylated adducts from the 0.position of guanine (section 7). With cisplatin and melphalan, the ability of the tumor cells to repa

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Book 2002llular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.