Titlebook: Clinical Xenotransplantation; Pathways and Progres David K. C. Cooper,Guerard Byrne Book 2020 Springer Nature Switzerland AG 2020 surgery.t

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Evolving Approaches to Treatment of Allosensitization and Antibody-Mediated Rejection these diseases. They have also rejuvenated interest in how B cells mediate multiple effector functions including antibody production, antigen presentation to T cells, costimulation, and the production of immune modulatory cytokines. Considerable experience in repurposing these drugs from autoimmuni

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Lessons from ABO-Incompatible Cardiac Allotransplantation in the Newborn transplantation of organs and tissues from animals into man, that is, xenotransplantation. For example, the scarcity of hearts of suitable size and condition for transplantation in newborn infants with severe cardiac failure, which motivated the use of ABO-incompatible hearts, also motivates consid

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e mapping of a concrete pathway to clinical xenotransplantation.??.The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following thi978-3-030-49129-1978-3-030-49127-7

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Scalable Multi-core Architecturesed immunosuppressive regimen, prevents early antibody-mediated and cellular rejection. However, low levels of anti-nonGal antibody and innate immune cells and/or platelets may initiate the development of a thrombotic microangiopathy in the graft that may be associated with a consumptive coagulopathy

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Inter-Domain AOM and Incremental Deployment,d continued improvements in donor pig genetic modification. Genetically engineered pig cells, devoid of the known xenogeneic glycans, minimize human antibody reactivity in 90% of human serum samples. For wait-listed patients, early comparisons of patient PRA and anti-pig antibody reactivity found no

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