Titlebook: Clinical Use of Calcium Channel Antagonist Drugs; Lionel H. Opie,William A. Coetzee Book 1989 Kluwer Academic Publishers, Boston 1989 angi

Benzodiazepines

Channel-Mediated Calcium Current in the Heart,isms, including several exhange mechanisms and pumps. This review concentrates on the influx of calcium ions through channels in the sarcolemma, resulting in an electric current flow. The calcium current plays an important role in the maintenance of the action potential duration, in the generation o

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perjury

Use and Comparative Properties of the Three Prototypical Calcium Antagonists in Ischemic Heart Disese syndromes. In effort angina, verapamil in a dose of 360–480 mg daily is better than propranolol in standard doses. Although nifedipine is highly effective against vasospastic angina, its use in threatened myocardial infarction or severe unstable angina is not supported by recent studies, unless c

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Use and Comparative Efficacy in Hypertension and Supraventricular Arrhythmias. Minor Indications,onses of the baroreflexes and the renin-angiotensin-aldosterone system. In severe hypertension, the concept that calcium overload of the vascular myocyte could precipitate or aggravate peripheral vasoconstriction provides a logical basis for the use of these agents as first choice therapy; nifedipin

FACT

Side Effects and Contraindications Drug Interactions and Combinations,effects. Almost all side effects are dose related. Minor side effects include those caused by vasodilation (flushing and headaches), constipation (verapamil), and ankle edema. Serious side effects are rare and result from improper use of these agents, as when intravenous verapamil (or diltiazem) is

CAB

Second-Generation Agents,ine. Verapamil-like agents include tiapamil, gallopamil, and anipamil. Among the diphenylalkylamines, bepridil is of special interest. New preparations of existing agents include slow-release formulations of nifedipine, verapamil, and diltiazem. From all these agents will be selected those that are

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https://doi.org/10.1007/978-3-319-02192-8ar importance are verapamil, nifedipine, and diltiazem, in historical order of appearance. These agents all have different molecular structures and bind separately with receptor sites located in or near the calcium channel, at molecular sites still to be fully identified. There are probably three di