Titlebook: Clinical Proteomics; Methods and Protocol Fernando J. Corrales,Alberto Paradela,Miguel Marci Book 2022 The Editor(s) (if applicable) and Th

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Lysine Acetylation Stoichiometry Analysis at the Proteome Level,ical pathways are targets of this PTM. The lysine acetylation is a reversible modification controlled by two main groups of enzymes, lysine acetyltransferases responsible for transferring the acetyl group of acetylCoA to the side chain of lysine residues and lysine deacetylases which effectively rem

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Implementation of Clinical Phosphoproteomics and Proteomics for Personalized Medicine,nt disease areas including cancer. Precision medicine is most frequently based on the detection of genomic markers that correlate with the efficacy of selected targeted therapies. However, since nongenetic mechanisms also contribute to disease biology, there is a considerable interest of using prote

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Generation of HLA Allele-Specific Spectral Libraries to Identify and Quantify Immunopeptidomes by Srred to as the immunopeptidome, is conducive to the success of a wide range of immunotherapies. The development of tools that enable the deconvolution of immunopeptidomes in the context of disease can help improve the specificity and effectiveness of therapeutic strategies targeting these peptides,

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Immunopeptidomic Analysis of the Phosphopeptidome Displayed by HLA Class I Molecules,s. In addition to conventional nonmodified peptides, these complex mixtures also contain phosphorylated species, which may be of great interest for personalized cancer immunotherapy. Here, we provide a detailed protocol to identify phosphopeptides displayed by human HLA class I molecules consisting

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Development of a Standardized MRM Method for the Quantification of One Carbon Metabolism Enzymes, alkylating agent in living cells, and glutathione, their most important nonenzymatic antioxidant defense. Impairment of 1CM in hepatocytes is a recognized factor associated to chronic liver disorders and hepatocellular carcinoma. With this in mind, we have proposed the concept of functional biomark

Multiple

Molecular Histology Analysis of Cryopreserved Tissue Using Peptide/Protein MALDI-TOF Imaging Mass Sion of peptides, small proteins, and other molecules within biological tissues. The obtained signals can be correlated with underlying tissue architecture, without any geometrical distortion, enabling the so-called molecular histology. Here, we analyzed cryopreserved tissue samples employing the MAL