Titlebook: Clinical Pharmacology in the Aged / Klinische Pharmakologie im Alter; Proceedings of the 6 Norbert Rietbrock (Professor),Barry G. Woodcock

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The Discontinuation of Digitalis Glycoside Therapy in the Elderlyalue of digitalis increases as heart failure progresses. Since heart failure advances with age, the “truth” appears to lie between the extremes: critical use but no rigorous withdrawal of digitalis glycosides in the elderly.

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Drug Distribution and Pharmacologic Effect: Relation to Drug Therapy in the Elderly body habitus associated with the aging process can lead to changes in patterns of drug distribution, which are independent of changes in clearance. Since drug distribution, rather than drug clearance, may be the most important determinant of the time-course and intensity of pharmacologic action aft

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