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Reform and Transition in the Mediterraneanceptor or 7TM superfamily) and that most are intronless genes has helped accelerate the cloning of this receptor family. The fact that the amino acid sequences of different serotonin receptors are among the least homologous of any single biogenic amine receptor family has had the opposite effect upo

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Reform and Transition in the Mediterraneanogical, pharmacological, and other investigative techniques provided evidence that 5-HT could act at presynaptic and postsynaptic sites and could be either excitatory or inhibitory in different systems; however, more definitive evidence of 5-HT receptor heterogeneity did not begin to emerge until th

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https://doi.org/10.1007/978-3-319-47479-3y, 5-HT has an inhibitory effect on dopaminergic output (see Meltzer and Nash 1991, for review). However, there is also evidence that 5-HT can enhance some aspects of dopaminergic function; thus, an over-simplistic one-way model should not be considered (Meltzer and Nash 1991). The effect of 5-HT in

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Challenges for Mechanism Design,e drugs were introduced in the 1950s, acute extrapyramidal syndromes have been associated with these neuroleptic agents. Indeed, the word “neuroleptic,” meaning “to take the neuron,” was intentionally created to encompass the concept that both antipsychotic benefits and motor side effects occurred a

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