Titlebook: Clinical Pharmacology & Therapeutics; Proceedings of Plena P. Turner,C. Padgham,A. Hedges Conference proceedings 1980 The contributors 1980

innate

吵鬧

遍及

Gene-Environment Interactions in Drug Metabolismlimination are often discussed as though such factors were entirely separate, unrelated entities without interaction or interdependence. However, genetic and environmental factors that control these large variations in rates of drug elimination interact dynamically at multiple levels. In fact, to ac

熱心

聯(lián)邦

Drug Metabolism at Various Ages — Younglized before they are excreted. The traditional concept about metabolic reactions is that of a deactivation process but an increasing number of drugs are now known to be metabolized to active or even toxic products (Drayer, 1976).

theta-waves

噴出

Renal Elimination of Drugs at Various Ages secretion, and/or active or passive tubular reabsorption (Weiner, 1971). Hydrophilic compounds, like the polycationic aminoglycosides, experience little passive reabsorption; their urine/plasma concentration ratios approximate 100, and their clearance is similar to that of inulin or creatinine. Lip

追逐

COMMA

The Effects of Digoxin on Red Cell Digitalis Receptor Function in Man). Bedside observation still holds prime place as a method for monitoring drug effects but more recently biochemical and pharmacological methods have been developed in attempts to provide information which might extend the interpretation of knowledge gained at the bedside. Principal among these has

Aphorism

Mechanisms for Regulation of β-Adrenergic Receptor Function in Desensitizationle of receptor alterations in mediating a variety of physiological changes in drug responsiveness. Among the more interesting properties of many biologically active agonist drugs is the fact that they not only stimulate target tissues but they also desensitize them. This means that after a period of