Titlebook: Circulating Tumor Cells in Breast Cancer Metastatic Disease; Roberto Pi?eiro Book 2020 Springer Nature Switzerland AG 2020 circulating tum

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,Introduction?– Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs,lyses may have in the clinic. However, their implementation in routine clinic has not been yet achieved due to the yet small body of evidence showing their clinical utility. This introductory chapter will revise the key aspects of breast cancer metastasis and discuss the importance of CTC analyses in the management of breast cancer patients.

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https://doi.org/10.1007/978-3-662-66215-1cular level and discuss the possible contribute of single cell analyses in precision medicine. We conclude with some remarks about the steps still necessary to achieve clinical validity and utility when considering also CTC phenotypic and molecular heterogeneity beyond a simple enumeration.

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https://doi.org/10.1007/978-3-662-66215-1his chapter we will focus on the most relevant technologies for CTC isolation based on their properties and depending on whether it is a positive or negative selection. We also describe each technology based on its potential use and its relevance in breast cancer. The chapter also contains a future

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https://doi.org/10.1007/978-3-322-92960-0gies for detection of CTCs and CTC clusters. However, more efficient methods are needed in order to address important questions regarding the metastatic potential of CTC and future clinical applications. In this chapter, we explore the current knowledge on the role of CTC clusters in breast cancer m

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Franz-Xaver Reichl,Michael Schwenko provide complementary information on the interplay of tumor cells with the immune system. The combination of different methods to detect tumoral disease by liquid biopsy may provide new ways to personalize in an unprecedented manner the management of patients with eBC.

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