Titlebook: Circulating Nucleic Acids in Plasma and Serum; Proceedings of the 6 Peter B. Gahan Conference proceedings 2011 Springer Science+Business Me

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Production of Transgenic Animalsansmission to the next generation of a modification appearing in part of a pluricellular organism. By proposing and demonstrating the existence of circulating DNA that is contained in a nucleoprotein particle – the virtosome – we refuted the germinal theory of Weisman on evolution. The virtosome also opens wide avenues in the field of medicine.

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Circulating Tumor-Related DNA Alterations as Prostate Cancer Biomarkerss, we have found that we can significantly improve the sensitivity of prostate cancer detection. These findings support the use of multimarker circulating DNA assays to detect prostate cancer, and justify further investigation to identify specific multimarker combinations associated with prostate ca

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Parallel Tagged 454 Sequencing for the Characterization of Circulating DNAthe control group. We concluded that the distribution of circulating DNA over the genome is similar for both groups even though some sequence related differences might be observed. Circulating DNA can be seen as a representation of genomic DNA in the blood of an individual.

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Blood Based Methylated DNA and Tumor-Specific Protein Analysis in Gastric Cancer Diagnostics. To conclude, epigenetic alterations of total cirDNA and elevated levels of tumor-associated proteins were found to be independently associated with gastric cancer indicating their usefulness as complementary diagnostic and prognostic markers for gastric cancer.

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Circulating Fetal DNA/RNA in Maternal Plasma for Aneuploidy Detectiony parallel sequencing platform for the direct detection of fetal chromosomal aneuploidies from maternal plasma. The analytical power of the latter approach with an unprecedented sensitivity, specificity, accuracy and precision has made it the most promising strategy for the clinical implementation o

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Introduction: Gene Expression in the Brain,s, we have found that we can significantly improve the sensitivity of prostate cancer detection. These findings support the use of multimarker circulating DNA assays to detect prostate cancer, and justify further investigation to identify specific multimarker combinations associated with prostate ca