Titlebook: Chronic Infectious Neuropathic Agents (CHINA) and other Slow Virus Infections; Jacob A. Brody,Werner Henle,Hilary Koprowski (Dire Conferen

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Chronic Infectious Neuropathic Agents: Possible Mechanisms of Pathogenesis,he long incubation period, (2) explaining the slow evolution of clinical disease and the unusual pathological findings often associated with these diseases, and (3) explaining the role of antibody in the prevention or causation of the disease. In the classic “slow virus infections” of sheep (., 1954

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Immune and Autoimmune Reactions in the Pathogenesis of Slow Virus Disease,nesis. Studies on lymphocytic choriomeningitis (LCM) virus infection in mice showed that animals which had been inoculated at birth could suffer from a long continued infection with high titers of virus (. 1961, 1962). This “persistent tolerant infection” (PTI) (. and ., 1961) was found to lead, aft

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Search for Infectious Etiology in Chronic and Subacute Degenerative Diseases of the Central Nervousdegenerative disease of the central nervous system, characterized by cerebellar ataxia and trembling, called “Kuru” by the New Guineans who suffer from it. This disease, restricted to some 12,000 natives of the Fore linguistic group indigenous to the Eastern Highlands of New Guinea and to their imme

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Discussion on Kuru, Scrapie and the Experimental Kuru-Like Syndrome in Chimpanzees,central nervous system of man in the Eastern Highlands of New Guinea and restricted to the Fore peoples and their immediate neighbors, have given rise to a large portion of world research activity in the field of slow virus infections. Dr. . has reviewed the quest for infectious agents in chronic an

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Chronic Infectious Neuropathic Agents: Possible Mechanisms of Pathogenesis, data exist to explain these curious phenomena in visna and scrapie, and discussion of their mechanisms of pathogenesis must rely largely on speculation and by analogy to other diseases. Several viruses, such as rabies, mumps, and lymphocytic choriomeningitis, provide more facile laboratory models a

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