Titlebook: Chromothripsis; Methods and Protocol Franck Pellestor Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Massive

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A Role for Retrotransposons in Chromothripsisf chromosomes. Following chromosomal shattering, DNA fragments are stitched together in a seemingly random manner resulting in complex genomic rearrangements including sequence shuffling, deletions, and inversions of varying size. This genomic catastrophe has been observed in cancer genomes and the

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Ceramic

Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instabilitydysfunction genomically, cellularly, and chromosomally, respectively. We used these approaches to study association between telomere dysfunction and degree of genomic instability related to TP53 mutations in LoVo isogenic cell lines. We found a strong correlation between degree of genomic instabilit

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Book 2018 Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the

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Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Eventsntroduce representative cases of human disorders arising from somatic or germline chromothripsis or similar catastrophic events. In this chapter, we use the term “chromoanagenesis” to indicate all catastrophic events including chromothripsis.

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Metabolism, Crisis, and Elasticityntroduce representative cases of human disorders arising from somatic or germline chromothripsis or similar catastrophic events. In this chapter, we use the term “chromoanagenesis” to indicate all catastrophic events including chromothripsis.

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