Titlebook: Chromosome Translocation; Yu Zhang Book 2018 Springer Nature Singapore Pte Ltd. 2018 Cancer.Chromosome Translocation.DNA repair.Genome Org

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Mary Jane Houlihan,Robert M. Goldwynromosomal translocations. Furthermore, the availability of viral vectors that express Cas9 has been critical to deliver the CRISPR/Cas9 system directly . to induce chromosomal rearrangements. This review provides an overview of the state-of-the-art CRISPR/Cas9 technology to model a variety of rearrangements . in animal models.

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Trial of Low Fat Diet for Protectionat regulate chromatin movement, focusing on studies exploring the motion properties of double-strand breaks in the context of chromatin, the functional consequences for DNA repair, and the formation of chromosome fusions.

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The Role of Chromosome Deletions in Human Cancers,n human cancer. In this chapter, we will focus on the latest studies on the functions of chromosome deletions in human cancers, especially hematopoietic malignancies and try to persuade the readers that these chromosome alterations could play significant roles?in the genesis and drug responses of human cancers.

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Book 2018mplications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation..It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases..

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Historical and Clinical Perspectives on Chromosomal Translocations,tely reported clinical phenotype resulting from a translocation was that of Down syndrome. In a small percentage of Down syndrome cases, an extra 21q is provided by a Robertsonian translocation chromosome, either occurring . or inherited from a phenotypically normal parent with the translocation chr